Role of RBM25/LUC7L3 in abnormal cardiac sodium channel splicing regulation in human heart failure.

ABSTRACT:

Background

Human heart failure is associated with decreased cardiac voltage-gated Na+ channel current (encoded by SCN5A), and the changes have been implicated in the increased risk of sudden death in heart failure. Nevertheless, the mechanism of SCN5A downregulation is unclear. A number of human diseases are associated with alternative mRNA splicing, which has received comparatively little attention in the study of cardiac disease. Splicing factor expression profiles during human heart failure and a specific splicing pathway for SCN5A regulation were explored in this study.

Methods and results

Gene array comparisons between normal human and heart failure tissues demonstrated that 17 splicing factors, associated with all major spliceosome components, were upregulated. Two of

SUBMITTER: Gao G 

PROVIDER: S-EPMC3172047 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature