Altered fusion dynamics underlie unique morphological changes in mitochondria during hypoxia-reoxygenation stress.

ABSTRACT: Functional states of mitochondria are often reflected in characteristic mitochondrial morphology. One of the most fundamental stress conditions, hypoxia-reoxygenation has been known to cause impaired mitochondrial function accompanied by structural abnormalities, but the underlying mechanisms need further investigation. Here, we monitored bioenergetics and mitochondrial fusion-fission in real time to determine how changes in mitochondrial dynamics contribute to structural abnormalities during hypoxia-reoxygenation. Hypoxia-reoxygenation resulted in the appearance of shorter mitochondria and a decrease in fusion activity. This fusion inhibition was a result of impaired ATP synthesis rather than Opa1 cleavage. A striking feature that appeared during hypoxia in glucose-free and during reoxyge

SUBMITTER: Liu X 

PROVIDER: S-EPMC3172112 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature