Longitudinal changes in adiponectin and inflammatory markers and relation to survival in the oldest old: the Cardiovascular Health Study All Stars study.

ABSTRACT:

Background

Adiponectin has anti-inflammatory properties, and its production is suppressed by inflammatory factors. Although elevated levels of adiponectin and inflammatory markers each predict mortality in older adults, the implications of their interdependent actions have not been examined.

Methods

We investigated the joint associations of levels and interval changes in adiponectin, C-reactive protein (CRP), and interleukin 6 (IL-6) with risk of death in 840 older adults participating in a population-based study. Adiponectin, CRP, and IL-6 were measured in samples collected 8.9 (8.2-9.8) years apart, and all-cause mortality was subsequently ascertained (n = 176).

Results

Interval changes and end levels of adiponectin, CRP, and IL-6 showed mostly positive, independent

SUBMITTER: Kizer JR 

PROVIDER: S-EPMC3172562 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature