The oxidized low-density lipoprotein receptor mediates vascular effects of inhaled vehicle emissions.

ABSTRACT:

Rationale

To determine vascular signaling pathways involved in inhaled air pollution (vehicular engine emission) exposure-induced exacerbation of atherosclerosis that are associated with onset of clinical cardiovascular events.

Objectives

To elucidate the role of oxidized low-density lipoprotein (oxLDL) and its primary receptor on endothelial cells, the lectin-like oxLDL receptor (LOX-1), in regulation of endothelin-1 expression and matrix metalloproteinase activity associated with inhalational exposure to vehicular engine emissions.

Methods

Atherosclerotic apolipoprotein E knockout mice were exposed by inhalation to filtered air or mixed whole engine emissions (250 μg particulate matter [PM]/m(3) diesel + 50 μg PM/m(3) gasoline exhausts) 6 h/d for 7 days. Concurrentl

SUBMITTER: Lund AK 

PROVIDER: S-EPMC3172889 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature