Clinical and radiographic predictors of GOLD-unclassified smokers in the COPDGene study.

ABSTRACT:

Rationale

A significant proportion of smokers have lung function impairment characterized by a reduced FEV(1) with a preserved FEV(1)/FVC ratio. These smokers are a poorly characterized group due to their systematic exclusion from chronic obstructive pulmonary disease (COPD) studies.

Objectives

To characterize the clinical, functional, and radiographic features of Global Initiative for Chronic Obstructive Lung Disease (GOLD)-Unclassified (FEV(1)/FVC ≥ 0.7 and FEV(1) < 80% predicted) and lower limits of normal (LLN)-unclassified (FEV(1)/FVC ≥ LLN and FEV(1) < LLN) subjects compared to smokers with normal lung function and subjects with COPD.

Methods

Data from the first 2,500 subjects enrolled in the COPDGene study were analyzed. All subjects had 10 or more pack-years o

SUBMITTER: Wan ES 

PROVIDER: S-EPMC3172890 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature