Exposure to cyclooxygenase-2 inhibitors and risk of cancer: nested case-control studies.

ABSTRACT:

Background

Selective cyclooxygenase-2 (COX2) inhibitors are widely used as analgesics and it is unclear whether its long-term use affects cancer risk.

Methods

A series of nested case-control studies using the QResearch primary care database. Associations of COX2 inhibitor use with risk of all cancers and 10 common site-specific cancers were estimated using conditional logistic regression adjusted for comorbidities, smoking status, socioeconomic status, and use of non-steroidal anti-inflammatory drugs, aspirin and statins.

Results

A total of 88,125 cancers, diagnosed between 1998 and 2008, matched with up to five controls, were analysed. Use of COX2 inhibitors for more than a year was associated with a significantly increased risk of breast cancer (odds ratio (OR) 1.24

SUBMITTER: Vinogradova Y 

PROVIDER: S-EPMC3172909 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature