Genome-wide association study of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Europe.

ABSTRACT:

Background

Stevens-Johnson syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are rare but extremely severe cutaneous adverse drug reactions in which drug-specific associations with HLA-B alleles were described.

Objectives

To investigate genetic association at a genome-wide level on a large sample of SJS/TEN patients.

Methods

We performed a genome wide association study on a sample of 424 European cases and 1,881 controls selected from a Reference Control Panel.

Results

Six SNPs located in the HLA region showed significant evidence for association (OR range: 1.53-1.74). The haplotype formed by their risk allele was more associated with the disease than any of the single SNPs and was even much stronger in patients exposed to allopurinol (OR(allopurinol) = 7.77,

SUBMITTER: Genin E 

PROVIDER: S-EPMC3173287 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature