The proteasome inhibitor MG132 reduces immobilization-induced skeletal muscle atrophy in mice.

ABSTRACT:

Background

Skeletal muscle atrophy is a serious concern for the rehabilitation of patients afflicted by prolonged limb restriction. This debilitating condition is associated with a marked activation of NFκB activity. The ubiquitin-proteasome pathway degrades the NFκB inhibitor IκBα, enabling NFκB to translocate to the nucleus and bind to the target genes that promote muscle atrophy. Although several studies showed that proteasome inhibitors are efficient to reduce atrophy, no studies have demonstrated the ability of these inhibitors to preserve muscle function under catabolic condition.

Methods

We recently developed a new hindlimb immobilization procedure that induces significant skeletal muscle atrophy and used it to show that an inflammatory process characterized by the up

SUBMITTER: Caron AZ 

PROVIDER: S-EPMC3173404 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature