Mitochondrial quality control during inheritance is associated with lifespan and mother-daughter age asymmetry in budding yeast.

ABSTRACT: Fluorescence loss in photobleaching experiments and analysis of mitochondrial function using superoxide and redox potential biosensors revealed that mitochondria within individual yeast cells are physically and functionally distinct. Mitochondria that are retained in mother cells during yeast cell division have a significantly more oxidizing redox potential and higher superoxide levels compared to mitochondria in buds. Retention of mitochondria with more oxidizing redox potential in mother cells occurs to the same extent in young and older cells and can account for the age-associated decline in total cellular mitochondrial redox potential in yeast as they age from 0 to 5 generations. Deletion of Mmr1p, a member of the DSL1 family of tethering proteins that localizes to mitochondria at the

SUBMITTER: McFaline-Figueroa JR 

PROVIDER: S-EPMC3173513 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature