A faster pedigree-based generalized multifactor dimensionality reduction method for detecting gene-gene interactions.

ABSTRACT: We proposed a faster pedigree-based generalized multifactor dimensionality reduction algorithm, called PedG-MDR II (PII), to detect gene-gene interactions underlying complex traits. Inherited from our previous framework of PedGMDR (PI), PII can handle both dichotomous and continuous traits in pedigree-based designs and allows for covariate adjustment. Compared with PI, this faster version can theoretically halve the computing burden and memory requirement. To evaluate the performance of PII, we performed comprehensive simulations across a wide variety of experimental scenarios, in which we considered two study designs, discordant sib pairs and mixed families of varying size, and, for each study design, we considered five common factors that may potentially affect statistical power: minor a

SUBMITTER: Chen GB 

PROVIDER: S-EPMC3173778 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature