Ontology highlight
ABSTRACT:
SUBMITTER: Mendoza-Naranjo A
PROVIDER: S-EPMC3173876 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Mendoza-Naranjo Ariadna A Bouma Gerben G Pereda Cristián C Ramírez Marcos M Webb Kevin F KF Tittarelli Andrés A López Mercedes N MN Kalergis Alexis M AM Thrasher Adrian J AJ Becker David L DL Salazar-Onfray Flavio F
Journal of immunology (Baltimore, Md. : 1950) 20110815 6
Gap junction (GJ) mediates intercellular communication through linked hemichannels from each of two adjacent cells. Using human and mouse models, we show that connexin 43 (Cx43), the main GJ protein in the immune system, was recruited to the immunological synapse during T cell priming as both GJs and stand-alone hemichannels. Cx43 accumulation at the synapse was Ag specific and time dependent, and required an intact actin cytoskeleton. Fluorescence recovery after photobleaching and Cx43-specific ...[more]