Different phenotypic and genotypic presentations in alcohol dependence: age at onset matters.

ABSTRACT:

Objective

Several theoretical typology models have been proposed to classify alcoholism into more homogeneous subtypes using various criteria, for which age at onset of alcohol dependence is shared across many models. We investigated the evidence for the distinction between early- versus late-onset alcoholism by examining relevant phenotypic and genotypic variables.

Method

Data are from 1,248 individuals with alcohol dependence, who were interviewed to collect detailed clinical information. Early versus late onset of alcohol dependence was defined by the age at onset of 22 years. Odds ratio (OR) and Cohen's d were calculated as effect size for comparisons of clinical features between the two groups. We adjusted interviewed age and gender in logistic regression models. Case-c

SUBMITTER: Chen YC 

PROVIDER: S-EPMC3174022 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature