Differences in the number of intrinsically disordered regions between yeast duplicated proteins, and their relationship with functional divergence.

ABSTRACT:

Background

Intrinsically disordered regions are enriched in short interaction motifs that play a critical role in many protein-protein interactions. Since new short interaction motifs may easily evolve, they have the potential to rapidly change protein interactions and cellular signaling. In this work we examined the dynamics of gain and loss of intrinsically disordered regions in duplicated proteins to inspect if changes after genome duplication can create functional divergence. For this purpose we used Saccharomyces cerevisiae and the outgroup species Lachancea kluyveri.

Principal findings

We find that genes duplicated as part of a genome duplication (ohnologs) are significantly more intrinsically disordered than singletons (p<2.2(e)-16, Wilcoxon), reflecting a preference

SUBMITTER: Montanari F 

PROVIDER: S-EPMC3174238 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature