ACTN3 genotype, athletic status, and life course physical capability: meta-analysis of the published literature and findings from nine studies.

ABSTRACT: The ACTN3 R577X (rs1815739) genotype has been associated with athletic status and muscle phenotypes, although not consistently. Our objective was to conduct a meta-analysis of the published literature on athletic status and investigate its associations with physical capability in several new population-based studies. Relevant data were extracted from studies in the literature, comparing genotype frequencies between controls and sprint/power and endurance athletes. For life course physical capability, data were used from two studies of adolescents and seven studies in the Healthy Ageing across the Life Course (HALCyon) collaborative research program, involving individuals aged between 53 and 90+ years. We found evidence from the published literature to support the hypothesis that in Europea

SUBMITTER: Alfred T 

PROVIDER: S-EPMC3174315 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature