Repertoire of porcine microRNAs in adult ovary and testis by deep sequencing.

ABSTRACT:

Background

MicroRNAs (miRNAs), a large family of short endogenous RNAs known to post-transcriptionally repress gene expression, participate in the regulation of almost every cellular process. Changes in miRNA expression are associated with many pathologies. Ovarian folliculogenesis and testicular spermatogenesis are complex and coordinated biological processes, in which tightly regulated expression and interaction of a multitude of genes could be regulated by these miRNAs. Identification and preliminary characterization of gonad-specific miRNAs would be a prerequisite for a thorough understanding of the role that miRNA-mediated posttranscriptional gene regulation plays in mammalian reproduction.

Method

Here, we present the identification of a repertoire of porcine miRNAs in

SUBMITTER: Li M 

PROVIDER: S-EPMC3174389 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature