Preserved arterial vasodilatation via endothelial protease-activated receptor-2 in obese type 2 diabetic mice.

ABSTRACT:

Background and purpose

In non-obese diabetic animals, protease-activated receptor-2 (PAR2) agonists are more effective vasodilators, which is attributed to increased COX-2 and endothelial NOS (eNOS) activities. Under conditions of diabetes and obesity, the effectiveness of PAR2 agonists is unknown. We compared the vasodilator responses of small calibre mesenteric arteries from obese diabetic B6.BKS(D)-Lepr(db) /J (db/db) induced by PAR2-activating agonists 2-furoyl-LIGRLO-amide (2fly) and trypsin to those obtained in controls [C57BL/6J (C57)], and assessed the contributions of COX, NOS and calcium-activated potassium channels (K(Ca)) to these responses.

Experimental approach

Arteries mounted in wire myographs under isometric tension conditions were contracted submaximally by

SUBMITTER: Kagota S 

PROVIDER: S-EPMC3174416 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature