Shared genetic background for regulation of mood and sleep: association of GRIA3 with sleep duration in healthy Finnish women.

ABSTRACT:

Study objectives

Sleeping 7 to 8 hours per night appears to be optimal, since both shorter and longer sleep times are related to increased morbidity and mortality. Depressive disorder is almost invariably accompanied by disturbed sleep, leading to decreased sleep duration, and disturbed sleep may be a precipitating factor in the initiation of depressive illness. Here, we examined whether, in healthy individuals, sleep duration is associated with genes that we earlier found to be associated with depressive disorder.

Design

Population-based molecular genetic study.

Setting

Regression analysis of 23 risk variants for depressive disorder from 12 genes to sleep duration in healthy individuals.

Participants

Three thousand, one hundred, forty-seven individuals (25-75

SUBMITTER: Utge S 

PROVIDER: S-EPMC3174833 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature