Metabolomic phenotyping of a cloned pig model.

ABSTRACT:

Background

Pigs are widely used as models for human physiological changes in intervention studies, because of the close resemblance between human and porcine physiology and the high degree of experimental control when using an animal model. Cloned animals have, in principle, identical genotypes and possibly also phenotypes and this offer an extra level of experimental control which could possibly make them a desirable tool for intervention studies. Therefore, in the present study, we address how phenotype and phenotypic variation is affected by cloning, through comparison of cloned pigs and normal outbred pigs.

Results

The metabolic phenotype of cloned pigs (n = 5) was for the first time elucidated by nuclear magnetic resonance (NMR)-based metabolomic analysis of multiple bi

SUBMITTER: Clausen MR 

PROVIDER: S-EPMC3174869 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature