Astrocyte-derived tissue transglutaminase interacts with fibronectin: a role in astrocyte adhesion and migration?

ABSTRACT: An important neuropathological feature of neuroinflammatory processes that occur during e.g. Multiple Sclerosis (MS) is the formation of an astroglial scar. Astroglial scar formation is facilitated by the interaction between astrocytes and extracellular matrix proteins (ECM) such as fibronectin. Since there is evidence indicating that glial scars strongly inhibit both axon growth and (re)myelination in brain lesions, it is important to understand the factors that contribute to the interaction between astrocytes and ECM proteins. Tissue Transglutaminase (TG2) is a multifunctional enzyme with an ubiquitous tissue distribution, being clearly present within the brain. It has been shown that inflammatory cytokines can enhance TG2 activity. In addition, TG2 can mediate cell adhesion and migratio

SUBMITTER: van Strien ME 

PROVIDER: S-EPMC3174992 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature