Genetic variation in the toll-like receptor 4 and prostate cancer incidence and mortality.

ABSTRACT:

Background

Common genetic variants in the Toll-like receptor 4 (TLR4), which is involved in inflammation and immune response pathways, may be important for prostate cancer.

Methods

In a large nested case-control study of prostate cancer in the Physicians' Health Study (1982-2004), 10 single nucleotide polymorphisms (SNPs) were selected and genotyped to capture common variation within the TLR4 gene as well as 5 kb up and downstream. Unconditional logistic regression was used to assess associations of these SNPs with total prostate cancer incidence, and with prostate cancers defined as advanced stage/lethal (T3/T4, M1/N1(T1-T4), lethal) or high Gleason grade (7 (4 + 3) or greater). Cox-proportional hazards regression was used to assess progression to metastases and death among

SUBMITTER: Shui IM 

PROVIDER: S-EPMC3175021 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature