Expression levels of estrogen receptor beta in conjunction with aromatase predict survival in non-small cell lung cancer.

ABSTRACT: Estrogen signaling pathways may play a significant role in the pathogenesis of non-small cell lung cancers (NSCLC) as evidenced by the expression of aromatase and estrogen receptors (ERα and ERβ) in many of these tumors. Here we examine whether ERα and ERβ levels in conjunction with aromatase define patient groups with respect to survival outcomes and possible treatment regimens. Immunohistochemistry was performed on a high-density tissue microarray with resulting data and clinical information available for 377 patients. Patients were subdivided by gender, age and tumor histology, and survival data was determined using the Cox proportional hazards model and Kaplan-Meier curves. Neither ERα nor ERβ alone was predictor of survival in NSCLC. However, when coupled with aromatase expression, hi

SUBMITTER: Mah V 

PROVIDER: S-EPMC3175023 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature