Diet intervention and cerebrospinal fluid biomarkers in amnestic mild cognitive impairment.

ABSTRACT:

Objective

To compare the effects of a 4-week high-saturated fat/high-glycemic index (HIGH) diet with a low-saturated fat/low-glycemic index (LOW) diet on insulin and lipid metabolism, cerebrospinal fluid (CSF) markers of Alzheimer disease, and cognition for healthy adults and adults with amnestic mild cognitive impairment (aMCI).

Design

Randomized controlled trial.

Setting

Veterans Affairs Medical Center clinical research unit.

Participants

Forty-nine older adults (20 healthy adults with a mean [SD] age of 69.3 [7.4] years and 29 adults with aMCI with a mean [SD] age of 67.6 [6.8] years).

Intervention

Participants received the HIGH diet (fat, 45% [saturated fat, > 25%]; carbohydrates, 35%-40% [glycemic index, > 70]; and protein, 15%-20%) or the LOW diet

SUBMITTER: Bayer-Carter JL 

PROVIDER: S-EPMC3175115 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature