A mathematical and computational approach for integrating the major sources of cell population heterogeneity.

ABSTRACT: Several approaches have been used in the past to model heterogeneity in bacterial cell populations, with each approach focusing on different source(s) of heterogeneity. However, a holistic approach that integrates all the major sources into a comprehensive framework applicable to cell populations is still lacking. In this work we present the mathematical formulation of a cell population master equation (CPME) that describes cell population dynamics and takes into account the major sources of heterogeneity, namely stochasticity in reaction, DNA-duplication, and division, as well as the random partitioning of species contents into the two daughter cells. The formulation also takes into account cell growth and respects the discrete nature of the molecular contents and cell numbers. We further

SUBMITTER: Stamatakis M 

PROVIDER: S-EPMC3175140 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature