Direct association between pharyngeal viral secretion and host cytokine response in severe pandemic influenza.

ABSTRACT:

Background

Severe disease caused by 2009 pandemic influenza A/H1N1virus is characterized by the presence of hypercytokinemia. The origin of the exacerbated cytokine response is unclear. As observed previously, uncontrolled influenza virus replication could strongly influence cytokine production. The objective of the present study was to evaluate the relationship between host cytokine responses and viral levels in pandemic influenza critically ill patients.

Methods

Twenty three patients admitted to the ICU with primary viral pneumonia were included in this study. A quantitative PCR based method targeting the M1 influenza gene was developed to quantify pharyngeal viral load. In addition, by using a multiplex based assay, we systematically evaluated host cytokine responses to t

SUBMITTER: Almansa R 

PROVIDER: S-EPMC3175217 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature