Sex hormones, insulin resistance, and diabetes mellitus among men with or at risk for HIV infection.

ABSTRACT:

Objective

To examine the relationship of free testosterone (FT) and sex hormone-binding globulin (SHBG) with insulin resistance and diabetes mellitus (DM) in HIV disease.

Design

Cross-sectional analysis from 322 HIV-uninfected and 534 HIV-infected men in the Multicenter AIDS Cohort Study.

Methods

: The main outcomes were DM and homeostasis model assessment-insulin resistance (HOMA-IR). DM was defined as fasting serum glucose ≥126 or self-reported DM and use of DM medications. HOMA-IR was calculated from fasting serum glucose and fasting insulin.

Results

Compared with HIV-uninfected men in our sample, HIV-infected men were younger, with lower body mass index, and more often black. HIV-infected men had lower FT (P < 0.001) and higher SHBG (P < 0.0001). The adjust

SUBMITTER: Monroe AK 

PROVIDER: S-EPMC3175332 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature