Neuropathologically defined subtypes of Alzheimer's disease with distinct clinical characteristics: a retrospective study.

ABSTRACT:

Background

Neurofibrillary pathology has a stereotypical progression in Alzheimer's disease (AD) that is encapsulated in the Braak staging scheme; however, some AD cases are atypical and do not fit into this scheme. We aimed to compare clinical and neuropathological features between typical and atypical AD cases.

Methods

AD cases with a Braak neurofibrillary tangle stage of more than IV were identified from a brain bank database. By use of thioflavin-S fluorescence microscopy, we assessed the density and the distribution of neurofibrillary tangles in three cortical regions and two hippocampal sectors. These data were used to construct an algorithm to classify AD cases into typical, hippocampal sparing, or limbic predominant. Classified cases were then compared for clinical,

SUBMITTER: Murray ME 

PROVIDER: S-EPMC3175379 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature