Effect of gestational hypercholesterolemia and maternal immunization on offspring plasma eicosanoids.

ABSTRACT:

Objective

Maternal immunization with oxidized low-density lipoprotein prior to pregnancy prevents pathogenic in utero programming by gestational hypercholesterolemia, but it is unknown whether gestational hypercholesterolemia and maternal immunization affect similar pathways.

Study design

A lipidomic approach was used for unbiased plasma eicosanoid profiling in adult offspring of immunized and nonimmunized normocholesterolemic or hypercholesterolemic rabbit mothers.

Results

Gestational hypercholesterolemia was associated with increased levels of some eicosanoids formed by the cyclooxygenase and 12-lipoxygenase pathways only (including thromboxane B2, prostaglandin [PG] F2α, PGE2, and PGD2). Immunization of hypercholesterolemic or normocholesterolemic mothers reduced 9

SUBMITTER: Quehenberger O 

PROVIDER: S-EPMC3175501 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature