No association of type 2 diabetes risk variants and prostate cancer risk: the multiethnic cohort and PAGE.

ABSTRACT:

Background

Epidemiologic studies have found evidence of an inverse association between diabetes status and prostate cancer risk. We explored the hypothesis that common genetic variation may explain, in part, the inverse association between diabetes and prostate cancer.

Methods

We tested 17 diabetes risk variants for association with prostate cancer risk in a prostate cancer case-control study of 2,746 cases and 3,317 controls from five racial/ethnic groups in the Multiethnic Cohort (MEC) study.

Results

After adjustment for multiple testing, none of the alleles were statistically significantly associated with prostate cancer risk. Aggregate scores that sum the risk alleles were also not significantly associated with risk.

Conclusions

We did not find evidence of

SUBMITTER: Waters KM 

PROVIDER: S-EPMC3175821 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature