Imaging retinal capillaries using ultrahigh-resolution optical coherence tomography and adaptive optics.

ABSTRACT:

Purpose

Ultrahigh-resolution optical coherence tomography (UHR-OCT) with adaptive optics (AO) provides micrometer-scale 3D resolution that is attractive for imaging the retinal microvasculature. Such imaging may be useful for early detection of pathologic changes as in diabetic retinopathy. Here the authors investigate this potential for detecting individual capillaries in healthy subjects.

Methods

UHR-AO-OCT volumes centered on the fovea were acquired from seven subjects (age range, 25-61 years) with three preselected with no foveal avascular zone (FAZ). Images were compared with entoptic diagrams using the capillaries at the rim of the FAZ. Methods of comparison were testing for the presence of a FAZ, noting distinct features in the capillary pattern, and measuring the siz

SUBMITTER: Wang Q 

PROVIDER: S-EPMC3175997 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature