The determinants of serum vitamin D levels in participants in a melanoma case-control study living in a temperate climate.

ABSTRACT:

Background

We report the determinants of serum levels of vitamin D in a U.K. melanoma case-control study benefitting from detailed exposure and genotyping data.

Methods

Sun exposure, supplemental vitamin D, and SNPs reported to be associated with serum levels were assessed as predictors of a single serum 25-hydroxyvitamin D3 measurement adjusted for season, age, sex, and body mass index.

Results

Adjusted analyses showed that vitamin D levels were sub-optimal especially in the sun-sensitive individuals (-2.61 nmol/L, p = 0.03) and for inheritance of a genetic variant in the GC gene coding for the vitamin D-binding protein (-5.79 for heterozygotes versus wild type, p = <0.0001). Higher levels were associated with sun exposure at the weekend in summer (+4.71 nmol/L per t

SUBMITTER: Davies JR 

PROVIDER: S-EPMC3176401 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature