Hippocampal sclerosis in temporal lobe epilepsy: findings at 7 T¹.

ABSTRACT:

Purpose

To determine if ultrahigh-field-strength magnetic resonance (MR) imaging can be used to detect subregional hippocampal alterations.

Materials and methods

Subjects provided written consent to participate in this prospective institutional review board-approved HIPAA-compliant study. T1- and T2-weighted 7-T brain MR images were acquired in 11 healthy subjects and eight patients with temporal lobe epilepsy (TLE). In all subjects, images were qualitatively examined for evidence of hippocampal atrophy, signal change, and malrotation with the Bernasconi definition, and digitations of the hippocampal heads were counted (agreement was measured with the κ statistic). Data were analyzed quantitatively with manual subregional hippocampal body segmentation. Subregional data in in

SUBMITTER: Henry TR 

PROVIDER: S-EPMC3176424 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature