Outcomes with concurrent use of clopidogrel and proton-pump inhibitors: a cohort study.

ABSTRACT:

Background

Proton-pump inhibitors (PPIs) and clopidogrel are frequently coprescribed, although the benefits and harms of their concurrent use are unclear.

Objective

To examine the association between concurrent use of PPIs and clopidogrel and the risks for hospitalizations for gastroduodenal bleeding and serious cardiovascular disease.

Design

Retrospective cohort study using automated data to identify patients who received clopidogrel between 1999 through 2005 after hospitalization for coronary heart disease.

Setting

Tennessee Medicaid program.

Patients

20,596 patients (including 7593 concurrent users of clopidogrel and PPIs) hospitalized for myocardial infarction, coronary artery revascularization, or unstable angina pectoris.

Measurements

Baseli

SUBMITTER: Ray WA 

PROVIDER: S-EPMC3176584 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature