Identification of novel Hoxa1 downstream targets regulating hindbrain, neural crest and inner ear development.

ABSTRACT: Hox genes play a crucial role during embryonic patterning and organogenesis. Of the 39 Hox genes, Hoxa1 is the first to be expressed during embryogenesis and the only anterior Hox gene linked to a human syndrome. Hoxa1 is necessary for the proper development of the brainstem, inner ear and heart in humans and mice; however, almost nothing is known about the molecular downstream targets through which it exerts its function. To gain insight into the transcriptional network regulated by this protein, we performed microarray analysis on tissue microdissected from the prospective rhombomere 3-5 region of Hoxa1 null and wild type embryos. Due to the very early and transient expression of this gene, dissections were performed on early somite stage embryos during an eight-hour time window of devel

SUBMITTER: Makki N 

PROVIDER: S-EPMC3176680 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature