Progesterone receptor gene polymorphisms and risk of endometriosis: results from an international collaborative effort.

ABSTRACT:

Objective

To investigate the association between self-reported endometriosis and the putative functional promoter +331C/T single nucleotide polymorphism and the PROGINS allele.

Design

Control subjects from ovarian cancer case-control studies participating in the international Ovarian Cancer Association Consortium. The majority of controls are drawn from population-based studies.

Setting

An international ovarian cancer consortium including studies from Australia, Europe, and the United States.

Patient(s)

Five thousand eight hundred twelve white female controls, of whom 348 had endometriosis, from eight ovarian cancer case-control studies.

Intervention(s)

None.

Main outcome measure(s)

Genotypes for the +331C/T single nucleotide polymorphism and PROG

SUBMITTER: Near AM 

PROVIDER: S-EPMC3176720 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature