Late replicating domains are highly recombining in females but have low male recombination rates: implications for isochore evolution.

ABSTRACT: In mammals sequences that are either late replicating or highly recombining have high rates of evolution at putatively neutral sites. As early replicating domains and highly recombining domains both tend to be GC rich we a priori expect these two variables to covary. If so, the relative contribution of either of these variables to the local neutral substitution rate might have been wrongly estimated owing to covariance with the other. Against our expectations, we find that sex-averaged recombination rates show little or no correlation with replication timing, suggesting that they are independent determinants of substitution rates. However, this result masks significant sex-specific complexity: late replicating domains tend to have high recombination rates in females but low recombination r

SUBMITTER: Pink CJ 

PROVIDER: S-EPMC3176772 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature