The effects of hourly differences in air pollution on the risk of myocardial infarction: case crossover analysis of the MINAP database.

ABSTRACT:

Objectives

To investigate associations between air pollution levels and myocardial infarction (MI) on short timescales, with data at an hourly temporal resolution.

Design

Time stratified case crossover study linking clinical data from the Myocardial Ischaemia National Audit Project (MINAP) with PM(10), ozone, CO, NO(2), and SO(2) data from the UK National Air Quality Archive. Pollution effects were investigated with delays (lags) of 1-6, 7-12, 13-18, 19-24, and 25-72 hours in both single and multi-pollutant models, adjusted for ambient temperature, relative humidity, circulating levels of influenza and respiratory syncytial virus, day of week, holidays, and residual seasonality within calendar month strata.

Setting

Population based study in 15 conurbations in England

SUBMITTER: Bhaskaran K 

PROVIDER: S-EPMC3176903 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature