Test-retest repeatability of MR elastography for noninvasive liver fibrosis assessment in hepatitis C.

ABSTRACT:

Purpose

To conduct a rigorous evaluation of the repeatability of liver stiffness assessed by MR elastography (MRE) in healthy and hepatitis-C-infected subjects.

Materials and methods

A biopsy-correlated repeatability study using four-slice MRE was conducted in five healthy and four HCV-infected subjects. Subjects were scanned twice on day 1 and after 7-14 days. Each slice was acquired during a 14-s breath-hold with a commercially available acquisition technique (MR-Touch, GE Healthcare). Results were analyzed by two independent analysts.

Results

The intraclass correlation coefficient (ICC) was 0.85 (90% confidence interval [CI]: 0.71 to 0.98) for the between-scan average of maximum stiffness within each slice and 0.88 (90% CI: 0.78 to 0.99) for the average of mean sti

SUBMITTER: Shire NJ 

PROVIDER: S-EPMC3176946 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature