Enhancers in embryonic stem cells are enriched for transposable elements and genetic variations associated with cancers.

ABSTRACT: Using an enhancer-associated epigenetic signature, we made genome-wide predictions of transcriptional enhancers in human B and T lymphocytes and embryonic stem cells (ES cells). We validated and characterized the predicted enhancers using four types of information, including overlap with other genomic marks for enhancers; association with cell-type-specific genes; enrichment of cell-type-specific transcription factor binding sites; and genetic polymorphisms in predicted enhancers. We find that enhancers from ES cells, but not B or T cells, are significantly enriched for DNA sequences derived from transposable elements. This may be due to the generally relaxed repressive epigenetic state and increased activity of transposable elements in ES cells. We demonstrate that the wealth of new enhan

SUBMITTER: Teng L 

PROVIDER: S-EPMC3177211 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature