Ability of dynamic airway pressure curve profile and elastance for positive end-expiratory pressure titration.

ABSTRACT:

Objective

To evaluate the ability of three indices derived from the airway pressure curve for titrating positive end-expiratory pressure (PEEP) to minimize mechanical stress while improving lung aeration assessed by computed tomography (CT).

Design

Prospective, experimental study.

Setting

University research facilities.

Subjects

Twelve pigs.

Interventions

Animals were anesthetized and mechanically ventilated with tidal volume of 7 ml kg(-1). In non-injured lungs (n = 6), PEEP was set at 16 cmH(2)O and stepwise decreased until zero. Acute lung injury was then induced either with oleic acid (n = 6) or surfactant depletion (n = 6). A recruitment maneuver was performed, the PEEP set at 26 cmH(2)O and decreased stepwise until zero. CT scans were obtained at e

SUBMITTER: Carvalho AR 

PROVIDER: S-EPMC3177558 | biostudies-literature | 2008 Dec

REPOSITORIES: biostudies-literature