Interpretation of transit compartments pharmacodynamic models as lifespan based indirect response models.

ABSTRACT: Transit compartments (TC) models are used to describe pharmacodynamic responses that involve drug action on cells undergoing differentiation and maturation. Such pharmacodynamic systems can also be described by lifespan based indirect response (LIDR) models. The purpose of this report is to investigate conditions under which the transit compartments models can be considered a special case of LIDR models. An integral representation of a solution to TC model has been used to determine the lifespan distribution for cell population described by this model. The distribution served as a basis for definition of new LIDRE (lifespan based indirect response with an effect on the lifespan distribution) models. Time courses of responses described by both types of models were simulated for a monoexpone

SUBMITTER: Krzyzanski W 

PROVIDER: S-EPMC3177953 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature