An SNP-Based Linkage Map for Zebrafish Reveals Sex Determination Loci.

ABSTRACT: A surprising diversity of mechanisms controls sex determination of vertebrate organisms, even among closely related species. Both genetic and temperature-dependent systems of sex determination have been described in teleost fish. In the common zebrafish model organism, heteromorphic sex chromosomes are not observed, and the potential role of a genetic component of sex determination remains largely unknown. Here we report a genome-wide linkage study of sex determination in zebrafish using a novel SNP genetic map. We identified loci on zebrafish chromosomes 5 (LOD score 7.9) and 16 (LOD score 9.3) governing sex determination as a complex trait, rather than as an XY or ZW genetic system. Each of these loci contains a prominent candidate gene with a conserved role in sex determination across a

SUBMITTER: Bradley KM 

PROVIDER: S-EPMC3178105 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature