Conjugate addition-initiated Nazarov cyclization.

ABSTRACT: A reaction sequence involving the 1,6-conjugate addition of a nucleophile to a dienyl diketone followed by Nazarov cyclization is described. Several nucleophiles are identified as competent initiators for the sequence. A different reaction outcome is observed when catalytic amounts of nucleophile are employed, involving elimination of the nucleophile after the electrocyclization.

SUBMITTER: Brooks JL 

PROVIDER: S-EPMC3178270 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature