Reduced serum vitamin D-binding protein levels are associated with type 1 diabetes.

ABSTRACT:

Objective

Previous studies have noted a specific association between type 1 diabetes and insufficient levels of vitamin D, as well as polymorphisms within genes related to vitamin D pathways. Here, we examined whether serum levels or genotypes of the vitamin D-binding protein (VDBP), a molecule key to the biologic actions of vitamin D, specifically associate with the disorder.

Research design and methods

A retrospective, cross-sectional analysis of VDBP levels used samples from 472 individuals of similar age and sex distribution, including 153 control subjects, 203 patients with type 1 diabetes, and 116 first-degree relatives of type 1 diabetic patients. Single nucleotide polymorphism (SNP) typing for VDBP polymorphisms (SNP rs4588 and rs7041) was performed on this cohort to

SUBMITTER: Blanton D 

PROVIDER: S-EPMC3178281 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature