Single-cell bioelectrical impedance platform for monitoring cellular response to drug treatment.

ABSTRACT: The response of cells to a chemical or biological agent in terms of their impedance changes in real-time is a useful mechanism that can be utilized for a wide variety of biomedical and environmental applications. The use of a single-cell-based analytical platform could be an effective approach to acquiring more sensitive cell impedance measurements, particularly in applications where only diminutive changes in impedance are expected. Here, we report the development of an on-chip cell impedance biosensor with two types of electrodes that host individual cells and cell populations, respectively, to study its efficacy in detecting cellular response. Human glioblastoma (U87MG) cells were patterned on single- and multi-cell electrodes through ligand-mediated natural cell adhesion. We comparativ

SUBMITTER: Asphahani F 

PROVIDER: S-EPMC3178809 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature