Tempo and mode of inhibitor-mutagen antiviral therapies: a multidisciplinary approach.

ABSTRACT: The continuous emergence of drug-resistant viruses is a major obstacle for the successful treatment of viral infections, thus representing a persistent spur to the search for new therapeutic strategies. Among them, multidrug treatments are currently at the forefront of pharmaceutical, clinical, and computational investigation. Still, there are many unknowns in the way that different drugs interact among themselves and with the pathogen that they aim to control. Inspired by experimental studies with picornavirus, here, we discuss the performance of sequential vs. combination therapies involving two dissimilar drugs: the mutagen ribavirin and an inhibitor of viral replication, guanidine. Because a systematic analysis of viral response to drug doses demands a precious amount of time and resou

SUBMITTER: Iranzo J 

PROVIDER: S-EPMC3179121 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature