No association of TNFRSF1B variants with type 2 diabetes in Indians of Indo-European origin.

ABSTRACT:

Background

There has been no systematic evaluation of the association between genetic variants of type 2 receptor for TNFα (TNFR2) and type 2 diabetes, despite strong biological evidence for the role of this receptor in the pathogenesis of this complex disorder. In view of this, we performed a comprehensive association analysis of TNFRSF1B variants with type 2 diabetes in 4,200 Indo-European subjects from North India.

Methods

The initial phase evaluated association of seven SNPs viz. rs652625, rs496888, rs6697733, rs945439, rs235249, rs17883432 and rs17884213 with type 2 diabetes in 2,115 participants (1,073 type 2 diabetes patients and 1,042 control subjects). Further, we conducted replication analysis of three associated SNPs in 2,085 subjects (1,047 type 2 diabetes patien

SUBMITTER: Tabassum R 

PROVIDER: S-EPMC3179441 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature