Identification of novel Pax8 targets in FRTL-5 thyroid cells by gene silencing and expression microarray analysis.

ABSTRACT:

Background

The differentiation program of thyroid follicular cells (TFCs), by far the most abundant cell population of the thyroid gland, relies on the interplay between sequence-specific transcription factors and transcriptional coregulators with the basal transcriptional machinery of the cell. However, the molecular mechanisms leading to the fully differentiated thyrocyte are still the object of intense study. The transcription factor Pax8, a member of the Paired-box gene family, has been demonstrated to be a critical regulator required for proper development and differentiation of thyroid follicular cells. Despite being Pax8 well-characterized with respect to its role in regulating genes involved in thyroid differentiation, genomics approaches aiming at the identification of add

SUBMITTER: Di Palma T 

PROVIDER: S-EPMC3179481 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature