Vitamin B12, cognition, and brain MRI measures: a cross-sectional examination.

ABSTRACT:

Objective

To investigate the interrelations of serum vitamin B12 markers with brain volumes, cerebral infarcts, and performance in different cognitive domains in a biracial population sample cross-sectionally.

Methods

In 121 community-dwelling participants of the Chicago Health and Aging Project, serum markers of vitamin B12 status were related to summary measures of neuropsychological tests of 5 cognitive domains and brain MRI measures obtained on average 4.6 years later among 121 older adults.

Results

Concentrations of all vitamin B12-related markers, but not serum vitamin B12 itself, were associated with global cognitive function and with total brain volume. Methylmalonate levels were associated with poorer episodic memory and perceptual speed, and cystathionine an

SUBMITTER: Tangney CC 

PROVIDER: S-EPMC3179651 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature