Regioselective reactions for programmable resveratrol oligomer synthesis.

ABSTRACT: Although much attention has been devoted to resveratrol, a unique polyphenol produced by plants and credited as potentially being responsible for the 'French paradox'--the observation that French people have a relatively low incidence of coronary heart disease, even though their diet is high in saturated fats--the oligomers of resveratrol have been largely ignored despite their high biological activity. Challenges in achieving their isolation in sufficient quantity from natural sources, coupled with an inability to prepare them easily synthetically, are seen as the main obstacles. Here we report a programmable, controlled and potentially scalable synthesis of the resveratrol family via a three-stage design. The synthetic approach requires strategy- and reagent-guided chemical functionaliza

SUBMITTER: Snyder SA 

PROVIDER: S-EPMC3179663 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature