CHRNA3 rs1051730 genotype and short-term smoking cessation.

ABSTRACT:

Introduction

The rs1051730 genetic variant within the CHRNA5-A3-B4 gene cluster is associated with heaviness of smoking and has recently been reported to be associated with likelihood of stopping smoking. We investigated the potential association of rs1051730 genotype with reduced likelihood of smoking cessation in 2 cohorts of treatment-seeking smokers in primary care in the United Kingdom.

Methods

Data were drawn from 2 clinical trials on which DNA was available. One sample was a randomized placebo-controlled trial of nicotine transdermal patch and the other sample an open-label trial where all participants received nicotine transdermal patch. Smoking status was biochemically verified. Logistic regression was used to assess evidence for association in each sample, and data

SUBMITTER: Munafo MR 

PROVIDER: S-EPMC3179672 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature